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The University of Calif., Davis' vet school is doing heavy duty DNA research into locating the epilepsy gene in Border Collies. They want as many samples as possible from border collies diagnosed with idiopathic epilepsy. If you have an epileptic dog, please take the time to participate in this study. With the advances in DNA technology and research, hopefully they can find the gene for epilepsy in our breed. Wouldn't be nice to be able to test for epilepsy like they can for CEA, CL and TNS?
Even if you have submitted blood samples before to another study, please take the time to submit a sample to UC Davis. The other vet school conducting epilepsy research is not focused on the border collie; they are focused on other breeds. Here is our opportunity to help OUR breed.
Study Start Dare; 11/1/2006
Study End Date: 10/31/2007
Genetics of Idiopathic Epilepsy in border collie dogs
Idiopathic epilepsy afflicts many breeds of domestic dog. Disease expression both across and within breeds highly variable (e.g. variation in age of onset and intensity, frequency, and duration of seizures). Best practices in the field of canine genetics and genomics now make it feasible to resolve complex diseased such as epilepsy by employing high density marker sets and using case-control association methodologies. toward this end. our laboratory is soliciting DNA samples, clinical records, and pedigree information from Border collies dogs that have exhibited seizures consistent with idiopathic epilepsy.
Study Design:
Case-controlled study
Sample Size:
100 dogs (50 affected, 50 control)
Inclusion Criteria:
The emphasis in sample collection is on border collie dogs that have exhibited seizures that are consistent with idiopathic epilepsy. a definitive diagnosis of epilepsy is generally considered unattainable (diagnosis by exclusion"), but several lines of evidence will be used to 'enrich' the case group animals for possessing casual factors.
Exclusion Criteria:
Dogs with structural causes of seizures, such as brain tumors, toxicities, etc.
Study Controls:
Control Border Collies that do not appear to be affected by epilepsy will be selected from the breed genealogical framework to control for confounding population variables such as stratification.
Samples:
3-5 ml of whole blood in ACD or EDTA vacutainer tubes are needed from border collies that have exhibited seizures. The blood should be sent by FedEx overnight at ambient temperature to our laboratory. UC Davis has a FedEx account number. Contact Katy Robertson (contact information below) to get the account number****
Contact Info and Sample shipping info:
c/o Katy Robertson
DNA collection
CCAH/CVG Bldg
Center for Veterinary genetics
UC Davis School of Veterinary Medicine
Davis, CA 95616-8744
[email protected](530) 752-3864
Full Disclosure Information
This study is funded by an institutional (university intramural) grant.
The investigators do not have any conflict of interest.
the study will be published if results are negative
The study will be reported on VIN
VIN will be acknowledging in publication if contributions are substantial.
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