Sandra Zilch ima na svoji strani zanimiv podatek:
"At the University of Giessen, the Institute for Phamocology and Toxicology, a study was carried out to determine Ivermoctic sensitivities in Collie-type breeds. The results showed that out of 700 tested dogs, the incidence of dogs affected by the MDR1-defect gene were Collies (~85%), Shetland Sheepdog (~50%), Australian Shepherd (~30%) and Border Collies (~3%)."
Sandra je predsednica DNA komisije za Evropo pri ASCA. In zdi se mi prav, da tukaj skopiram novico v zvezi s CMR z njene spletne strani, saj je primer dobre prakse odgovornega vzreditelja:
"The up to now in Australian Shepherds rather unknown disease CMR (Canine Multifocal Rethinoplasia) was diagnosed in a dog that is a descendant from two dogs we have bred. These dogs are S Bar L Mohawk and S Bar L Yakima, both owned by Susanne Schwarzmann in Austria. These dogs are, according to the Veterinärmedizinischen Universität Wien, carriers of the mutation. One female out of these dogs has the disease and thats why we became aware of the defect. We are in the process to have all relatives of these dogs tested for CMR to get a Status Quo.
In case we have forgotten to inform one of our puppy buyers who has relatives, we are sorry and we would like you to contact us please.
The disease was up to now known in Pyrenean Mountain Dogs, English- and Bullmastiffs and in Coton de Tulear. Its an inherited disease and its passed on autosomal recessive. This means, that there need to be two copies present in a dog for the disease to be diagnosed. A dog that has one copy will not get it. Therefore, breeding wise, it will be handled like MDR1. Although the retina will show some defects, there is no loss of vision reported.
Optigen says: „The disease generally develops in young dogs before 4 months and might progress slowly, might appear to heal, or might even appear and then go away again. Some dogs affected with CMR do not show clinical symptoms of disease until later in life. (...) Most dogs exhibit no noticeable problem with vision despite their abnormal appearing retinas. And in almost all cases, CMR does not progress significantly over time. The disease seems to have a consistent pattern among the breeds.“
So, there is no reason for panic. It seems not to be too difficult to get this under control and we are taking this serious. Maybe we will also do another, second testing with our dogs with another lab, just to make sure. (There have been cases before with two different HSF4 test results from two different labs before, for example.)
We will inform you here when we have new information.
According to the test done by Optigen, the result is: Nell +/+, Rufi +/- und Blue +/-."
Torej, BINGO. martina.o, koliko takih FCI vzrediteljev poznaš?